Probing myocardium biomechanics using quantitative optical coherence elastography

Shang Wang, Andrew L. Lopez, Yuka Morikawa, Ge Tao, Jiasong Li, Irina V. Larina, James F. Martin, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

We present a quantitative optical coherence elastographic method for noncontact assessment of the myocardium elasticity. The method is based on shear wave imaging optical coherence tomography (SWI-OCT), where a focused air-puff system is used to induce localized tissue deformation through a low-pressure short-duration air stream and a phase-sensitive OCT system is utilized to monitor the propagation of the induced tissue displacement with nano-scale sensitivity. The 1-D scanning of M-mode OCT imaging and the application of optical phase retrieval and mapping techniques enable the reconstruction and visualization of 2-D depth-resolved shear wave propagation in tissue with ultra-high frame rate. The feasibility of this method in quantitative elasticity measurement is demonstrated on tissue-mimicking phantoms with the estimated Young's modulus compared with uniaxial compression tests. We also performed pilot experiments on ex vivo mouse cardiac muscle tissues with normal and genetically altered cardiomyocytes. Our results indicate this noncontact quantitative optical coherence elastographic method can be a useful tool for the cardiac muscle research and studies.

Original languageEnglish
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX
EditorsValery V. Tuchin, James G. Fujimoto, Joseph A. Izatt
ISBN (Electronic)9781628414028
DOIs
StatePublished - 2015
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX - San Francisco, United States
Duration: 8 Feb 201511 Feb 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9312
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX
Country/TerritoryUnited States
CitySan Francisco
Period8/02/1511/02/15

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