@inproceedings{9ea6afd73dcd4fb4a2aeced201394e95,
title = "Probing myocardium biomechanics using quantitative optical coherence elastography",
abstract = "We present a quantitative optical coherence elastographic method for noncontact assessment of the myocardium elasticity. The method is based on shear wave imaging optical coherence tomography (SWI-OCT), where a focused air-puff system is used to induce localized tissue deformation through a low-pressure short-duration air stream and a phase-sensitive OCT system is utilized to monitor the propagation of the induced tissue displacement with nano-scale sensitivity. The 1-D scanning of M-mode OCT imaging and the application of optical phase retrieval and mapping techniques enable the reconstruction and visualization of 2-D depth-resolved shear wave propagation in tissue with ultra-high frame rate. The feasibility of this method in quantitative elasticity measurement is demonstrated on tissue-mimicking phantoms with the estimated Young's modulus compared with uniaxial compression tests. We also performed pilot experiments on ex vivo mouse cardiac muscle tissues with normal and genetically altered cardiomyocytes. Our results indicate this noncontact quantitative optical coherence elastographic method can be a useful tool for the cardiac muscle research and studies.",
author = "Shang Wang and Lopez, {Andrew L.} and Yuka Morikawa and Ge Tao and Jiasong Li and Larina, {Irina V.} and Martin, {James F.} and Larin, {Kirill V.}",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX ; Conference date: 08-02-2015 Through 11-02-2015",
year = "2015",
doi = "10.1117/12.2078390",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
editor = "Tuchin, {Valery V.} and Fujimoto, {James G.} and Izatt, {Joseph A.}",
booktitle = "Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX",
}