Protein engineering of a viral cage for constrained nanomaterials synthesis

T. Douglas, E. Strable, D. Willits, A. Aitouchen, M. Libera, M. Young

Research output: Contribution to journalArticlepeer-review

354 Scopus citations

Abstract

Cage architectures based on the cowpea chlorotic mottle virus were used to achieve a synthetic mimic of the iron storage protein ferritin. The electrostatic nature of the inner protein surface could be changed by up to 3240 units of charge, while still maintaining a stable cage structure. The spatial isolation within the protein cage prevented bulk aggregation of the mineral particles and resulted in a stable, mono-disperse colloid.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalAdvanced Materials
Volume14
Issue number6
DOIs
StatePublished - 18 Mar 2002

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