Pt(IV) complexes loaded hollow copper sulfide nanoparticles for tumor chemo/photothermal/photodynamic therapy

Quan Bing Chen, Meng Qi, Meng Yang, Zi Qiang Luo, Qiong Yuan, Tao Peng, Jing Wang, Tao Zou, Hongjun Wang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Hollow CuS nanoparticles can achieve photothermal and photodynamic therapy (PDT) in tumor treatment. However, excessive GSH in the tumor cells will consume the reactive oxygen species produced by PDT and reduce the PDT effect. Cisplatin is a broad-spectrum antineoplastic drug that can be used in a variety of tumor treatments. However, cisplatin is cytotoxic to normal cells while it kills tumor cells. Therefore, we construct Pt(IV) complexes loaded hollow CuS nanoparticles to attenuate the toxicity of cisplatin and enhance the PDT effect of the hollow CuS nanoparticles. The nanoparticles were proved to be able to accumulate around the tumor site through the enhanced permeability and retention (EPR) effect to achieve a synergistic chemo/photothermal/photodynamic therapy.

Original languageEnglish
Article number114076
JournalColloids and Surfaces B: Biointerfaces
Volume242
DOIs
StatePublished - Oct 2024

Keywords

  • Copper sulfide
  • Nanoparticle
  • Platinum
  • Tumor therapy

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