Quantitative 4D OCT imaging of tubular mouse embryonic heart reveals its localized pumping mechanism

Shang Wang, Riana Syed, Irina V. Larina

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present an imaging-based quantitative approach for studying the localized pumping mechanism of the early tubular heart in live mouse embryos. The method relies on 4D (3D+time) imaging of cardiodynamics and hemodynamics of the embryonic heart using structural and Doppler optical coherence tomography (OCT). Our results from the mouse embryo at embryonic day 9.0 (E9.0) show an interesting relationship between the endocardial luminal areas and the localized volumetric blood flows, suggesting that a localized pressure gradient induced by the heart wall movement causes the variation of blood flows, including both the velocity magnitude and flow direction. Data provide new insights into the pumping mechanism of the mammalian tubular heart at the early developmental stage.

Original languageEnglish
Title of host publicationDynamics and Fluctuations in Biomedical Photonics XVII
EditorsValery V. Tuchin, Valery V. Tuchin, Martin J. Leahy, Ruikang K. Wang
ISBN (Electronic)9781510632417
DOIs
StatePublished - 2020
EventDynamics and Fluctuations in Biomedical Photonics XVII 2020 - San Francisco, United States
Duration: 1 Feb 20203 Feb 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11239
ISSN (Print)1605-7422

Conference

ConferenceDynamics and Fluctuations in Biomedical Photonics XVII 2020
Country/TerritoryUnited States
CitySan Francisco
Period1/02/203/02/20

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