Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh-Lamb equation

Zhaolong Han, Salavat R. Aglyamov, Jiasong Li, Manmohan Singh, Shang Wang, Srilatha Vantipalli, Chen Wu, Chih Hao Liu, Michael D. Twa, Kirill V. Larin

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

We demonstrate the use of a modified Rayleigh-Lamb frequency equation in conjunction with noncontact optical coherence elastography to quantify the viscoelastic properties of the cornea. Phase velocities of air-pulse-induced elastic waves were extracted by spectral analysis and used for calculating the Young's moduli of the samples using the Rayleigh-Lamb frequency equation (RLFE). Validation experiments were performed on 2% agar phantoms (n = 3) and then applied to porcine corneas (n = 3) in situ. The Young's moduli of the porcine corneas were estimated to be ∼60 kPa with a shear viscosity ∼0.33 Pa · s. The results demonstrate that the RLFE is a promising method for noninvasive quantification of the corneal biomechanical properties and may potentially be useful for clinical ophthalmological applications.

Original languageEnglish
Article number020501
JournalJournal of Biomedical Optics
Volume20
Issue number2
DOIs
StatePublished - 1 Feb 2015

Keywords

  • Rayleigh-Lamb frequency model
  • cornea
  • optical coherence elastography
  • viscoelasticity

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