TY - JOUR
T1 - Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh-Lamb equation
AU - Han, Zhaolong
AU - Aglyamov, Salavat R.
AU - Li, Jiasong
AU - Singh, Manmohan
AU - Wang, Shang
AU - Vantipalli, Srilatha
AU - Wu, Chen
AU - Liu, Chih Hao
AU - Twa, Michael D.
AU - Larin, Kirill V.
N1 - Publisher Copyright:
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE).
PY - 2015/2/1
Y1 - 2015/2/1
N2 - We demonstrate the use of a modified Rayleigh-Lamb frequency equation in conjunction with noncontact optical coherence elastography to quantify the viscoelastic properties of the cornea. Phase velocities of air-pulse-induced elastic waves were extracted by spectral analysis and used for calculating the Young's moduli of the samples using the Rayleigh-Lamb frequency equation (RLFE). Validation experiments were performed on 2% agar phantoms (n = 3) and then applied to porcine corneas (n = 3) in situ. The Young's moduli of the porcine corneas were estimated to be ∼60 kPa with a shear viscosity ∼0.33 Pa · s. The results demonstrate that the RLFE is a promising method for noninvasive quantification of the corneal biomechanical properties and may potentially be useful for clinical ophthalmological applications.
AB - We demonstrate the use of a modified Rayleigh-Lamb frequency equation in conjunction with noncontact optical coherence elastography to quantify the viscoelastic properties of the cornea. Phase velocities of air-pulse-induced elastic waves were extracted by spectral analysis and used for calculating the Young's moduli of the samples using the Rayleigh-Lamb frequency equation (RLFE). Validation experiments were performed on 2% agar phantoms (n = 3) and then applied to porcine corneas (n = 3) in situ. The Young's moduli of the porcine corneas were estimated to be ∼60 kPa with a shear viscosity ∼0.33 Pa · s. The results demonstrate that the RLFE is a promising method for noninvasive quantification of the corneal biomechanical properties and may potentially be useful for clinical ophthalmological applications.
KW - Rayleigh-Lamb frequency model
KW - cornea
KW - optical coherence elastography
KW - viscoelasticity
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U2 - 10.1117/1.JBO.20.2.020501
DO - 10.1117/1.JBO.20.2.020501
M3 - Article
C2 - 25649624
AN - SCOPUS:84922576101
SN - 1083-3668
VL - 20
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 2
M1 - 020501
ER -