Quantitative assessment of hyaline cartilage elasticity during optical clearing using optical coherence elastography

Chih Hao Liu, Manmohan Singh, Jiasong Li, Zhaolong Han, Chen Wu, Shang Wang, Rita Idugboe, Raksha Raghunathan, Valery P. Zakharov, Emil N. Sobol, Valery V. Tuchin, Michael Twa, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We report the first study on using optical coherence elastography (OCE) to quantitatively monitor the elasticity change of the hyaline cartilage during the optical clearing administrated by glucose solution. The measurement of the elasticity is verified using uniaxial compression test, demonstrating the feasibility of using OCE to quantify the Young's modulus of the cartilage tissue. As the results, we found that the stiffness of the hyaline cartilage increases during the optical clearing of the tissue. This study might be potentially useful for the early detection of osteoarthritis disease.

Original languageEnglish
Title of host publicationDynamics and Fluctuations in Biomedical Photonics XII
EditorsKirill V. Larin, Martin J. Leahy, Ruikang K. Wang, Valery V. Tuchin, Valery V. Tuchin
ISBN (Electronic)9781628414127
DOIs
StatePublished - 2015
EventDynamics and Fluctuations in Biomedical Photonics XII - San Francisco, United States
Duration: 7 Feb 20158 Feb 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9322
ISSN (Print)1605-7422

Conference

ConferenceDynamics and Fluctuations in Biomedical Photonics XII
Country/TerritoryUnited States
CitySan Francisco
Period7/02/158/02/15

Keywords

  • Hyaline cartilage
  • Optical clearing
  • Optical coherence elastography
  • Young's modulus

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