Quantitative methods for reconstructing tissue biomechanical properties in optical coherence elastography: A comparison study

Zhaolong Han, Jiasong Li, Manmohan Singh, Chen Wu, Chih Hao Liu, Shang Wang, Rita Idugboe, Raksha Raghunathan, Narendran Sudheendran, Salavat R. Aglyamov, Michael D. Twa, Kirill V. Larin

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

We present a systematic analysis of the accuracy of five different methods for extracting the biomechanical properties of soft samples using optical coherence elastography (OCE). OCE is an emerging noninvasive technique, which allows assessment of biomechanical properties of tissues with micrometer spatial resolution. However, in order to accurately extract biomechanical properties from OCE measurements, application of a proper mechanical model is required. In this study, we utilize tissue-mimicking phantoms with controlled elastic properties and investigate the feasibilities of four available methods for reconstructing elasticity (Young's modulus) based on OCE measurements of an air-pulse induced elastic wave. The approaches are based on the shear wave equation(SWE), the surface wave equation(SuWE), Rayleigh-Lamb frequency equation(RLFE), and finite element method (FEM), Elasticity values were compared with uniaxial mechanical testing. The results show that the RLFE and the FEM are more robust in quantitatively assessing elasticity than the other simplified models. This study provides a foundation and reference for reconstructing the biomechanical properties of tissues from OCE data, which is important for the further development of noninvasive elastography methods.

Original languageEnglish
Pages (from-to)3531-3547
Number of pages17
JournalPhysics in Medicine and Biology
Volume60
Issue number9
DOIs
StatePublished - 7 May 2015

Keywords

  • Rayleigh-Lamb frequency equation
  • elastic wave
  • finite element method
  • optical coherence elastography (OCE)
  • phase velocity
  • tissuemimicking phantom

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