TY - JOUR
T1 - Quantitative methods for reconstructing tissue biomechanical properties in optical coherence elastography
T2 - A comparison study
AU - Han, Zhaolong
AU - Li, Jiasong
AU - Singh, Manmohan
AU - Wu, Chen
AU - Liu, Chih Hao
AU - Wang, Shang
AU - Idugboe, Rita
AU - Raghunathan, Raksha
AU - Sudheendran, Narendran
AU - Aglyamov, Salavat R.
AU - Twa, Michael D.
AU - Larin, Kirill V.
N1 - Publisher Copyright:
© 2015 Institute of Physics and Engineering in Medicine.
PY - 2015/5/7
Y1 - 2015/5/7
N2 - We present a systematic analysis of the accuracy of five different methods for extracting the biomechanical properties of soft samples using optical coherence elastography (OCE). OCE is an emerging noninvasive technique, which allows assessment of biomechanical properties of tissues with micrometer spatial resolution. However, in order to accurately extract biomechanical properties from OCE measurements, application of a proper mechanical model is required. In this study, we utilize tissue-mimicking phantoms with controlled elastic properties and investigate the feasibilities of four available methods for reconstructing elasticity (Young's modulus) based on OCE measurements of an air-pulse induced elastic wave. The approaches are based on the shear wave equation(SWE), the surface wave equation(SuWE), Rayleigh-Lamb frequency equation(RLFE), and finite element method (FEM), Elasticity values were compared with uniaxial mechanical testing. The results show that the RLFE and the FEM are more robust in quantitatively assessing elasticity than the other simplified models. This study provides a foundation and reference for reconstructing the biomechanical properties of tissues from OCE data, which is important for the further development of noninvasive elastography methods.
AB - We present a systematic analysis of the accuracy of five different methods for extracting the biomechanical properties of soft samples using optical coherence elastography (OCE). OCE is an emerging noninvasive technique, which allows assessment of biomechanical properties of tissues with micrometer spatial resolution. However, in order to accurately extract biomechanical properties from OCE measurements, application of a proper mechanical model is required. In this study, we utilize tissue-mimicking phantoms with controlled elastic properties and investigate the feasibilities of four available methods for reconstructing elasticity (Young's modulus) based on OCE measurements of an air-pulse induced elastic wave. The approaches are based on the shear wave equation(SWE), the surface wave equation(SuWE), Rayleigh-Lamb frequency equation(RLFE), and finite element method (FEM), Elasticity values were compared with uniaxial mechanical testing. The results show that the RLFE and the FEM are more robust in quantitatively assessing elasticity than the other simplified models. This study provides a foundation and reference for reconstructing the biomechanical properties of tissues from OCE data, which is important for the further development of noninvasive elastography methods.
KW - Rayleigh-Lamb frequency equation
KW - elastic wave
KW - finite element method
KW - optical coherence elastography (OCE)
KW - phase velocity
KW - tissuemimicking phantom
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U2 - 10.1088/0031-9155/60/9/3531
DO - 10.1088/0031-9155/60/9/3531
M3 - Article
C2 - 25860076
AN - SCOPUS:84928492287
SN - 0031-9155
VL - 60
SP - 3531
EP - 3547
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
IS - 9
ER -