TY - JOUR
T1 - Quantitative retinal blood flow mapping from fluorescein videoangiography using tracer kinetic modeling
AU - Tichauer, Kenneth M.
AU - Guthrie, Micah
AU - Hones, Logan
AU - Sinha, Lagnojita
AU - Lawrence, Keith St
AU - Kang-Mieler, Jennifer J.
N1 - Publisher Copyright:
© 2015 Optical Society of America.
PY - 2015
Y1 - 2015
N2 - Abnormal retinal blood flow (RBF) has been associated with numerous retinal pathologies, yet existing methods for measuring RBF predominantly provide only relative measures of blood flow and are unable to quantify volumetric blood flow, which could allow direct patient to patient comparison. This work presents a methodology based on linear systems theory and an image-based arterial input function to quantitatively map volumetric blood flow from standard fluorescein videoangiography data, and is therefore directly translatable to the clinic. Application of the approach to fluorescein retinal videoangiography in rats (4 control, 4 diabetic) demonstrated significantly higher RBF in 4-5 week diabetic rats as expected from the literature.
AB - Abnormal retinal blood flow (RBF) has been associated with numerous retinal pathologies, yet existing methods for measuring RBF predominantly provide only relative measures of blood flow and are unable to quantify volumetric blood flow, which could allow direct patient to patient comparison. This work presents a methodology based on linear systems theory and an image-based arterial input function to quantitatively map volumetric blood flow from standard fluorescein videoangiography data, and is therefore directly translatable to the clinic. Application of the approach to fluorescein retinal videoangiography in rats (4 control, 4 diabetic) demonstrated significantly higher RBF in 4-5 week diabetic rats as expected from the literature.
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U2 - 10.1364/OL.40.002169
DO - 10.1364/OL.40.002169
M3 - Article
C2 - 26393691
AN - SCOPUS:84981294866
SN - 0146-9592
VL - 40
SP - 2169
EP - 2172
JO - Optics Letters
JF - Optics Letters
IS - 10
ER -