Raman Spectroscopic Imaging Technology and Its Biomedical Applications

Jiao Lu, Shanshan Zhu, Xiaoyu Cui, Shuo Chen, Yudong Yao

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Raman spectroscopy is an analytical tool for chemical compositions and structures of molecules. Because it is a non-invasive technique with rich biochemical information, minimal sample preparation and little interference of water, Raman spectroscopy has been widely used in the field of biomedicine. Raman spectroscopic imaging is the combination of Raman spectroscopy and imaging, which collects Raman spectrum at each pixel for the entire region. Thus, both spatial and spectral information can be captured for positioning analysis of material molecules qualitatively and quantificationally. Compared with traditional Raman spectroscopy, Raman imaging can provide additional spatial information about the sample, which is extremely important for biomedical applications. Therefore, Raman spectroscopic imaging technique with both biochemical and spatial information shows significant values in the field of biomedicine, such as biological sample examination, clinical diagnosis, and treatment. The Raman spectroscopy technique and its development are introduced based on the principle of Raman spectroscopy. The application of Raman spectroscopy technique in the field of biomedicine in recent years is summarized. Finally, the summary and prospects of Raman spectroscopic imaging technology are discussed.

Original languageEnglish
Article number0307007
JournalZhongguo Jiguang/Chinese Journal of Lasers
Volume45
Issue number3
DOIs
StatePublished - 10 Mar 2018

Keywords

  • Biology and medicine
  • Imaging
  • Medical optics
  • Raman spectroscopic imaging
  • Raman spectroscopy

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