TY - JOUR
T1 - Regeneration of severely damaged lungs using an interventional cross-circulation platform
AU - Guenthart, Brandon A.
AU - O’Neill, John D.
AU - Kim, Jinho
AU - Queen, Dawn
AU - Chicotka, Scott
AU - Fung, Kenmond
AU - Simpson, Michael
AU - Donocoff, Rachel
AU - Salna, Michael
AU - Marboe, Charles C.
AU - Cunningham, Katherine
AU - Halligan, Susan P.
AU - Wobma, Holly M.
AU - Hozain, Ahmed E.
AU - Romanov, Alexander
AU - Vunjak-Novakovic, Gordana
AU - Bacchetta, Matthew
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The number of available donor organs limits lung transplantation, the only lifesaving therapy for the increasing population of patients with end-stage lung disease. A prevalent etiology of injury that renders lungs unacceptable for transplantation is gastric aspiration, a deleterious insult to the pulmonary epithelium. Currently, severely damaged donor lungs cannot be salvaged with existing devices or methods. Here we report the regeneration of severely damaged lungs repaired to meet transplantation criteria by utilizing an interventional cross-circulation platform in a clinically relevant swine model of gastric aspiration injury. Enabled by cross-circulation with a living swine, prolonged extracorporeal support of damaged lungs results in significant improvements in lung function, cellular regeneration, and the development of diagnostic tools for non-invasive organ evaluation and repair. We therefore propose that the use of an interventional cross-circulation platform could enable recovery of otherwise unsalvageable lungs and thus expand the donor organ pool.
AB - The number of available donor organs limits lung transplantation, the only lifesaving therapy for the increasing population of patients with end-stage lung disease. A prevalent etiology of injury that renders lungs unacceptable for transplantation is gastric aspiration, a deleterious insult to the pulmonary epithelium. Currently, severely damaged donor lungs cannot be salvaged with existing devices or methods. Here we report the regeneration of severely damaged lungs repaired to meet transplantation criteria by utilizing an interventional cross-circulation platform in a clinically relevant swine model of gastric aspiration injury. Enabled by cross-circulation with a living swine, prolonged extracorporeal support of damaged lungs results in significant improvements in lung function, cellular regeneration, and the development of diagnostic tools for non-invasive organ evaluation and repair. We therefore propose that the use of an interventional cross-circulation platform could enable recovery of otherwise unsalvageable lungs and thus expand the donor organ pool.
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U2 - 10.1038/s41467-019-09908-1
DO - 10.1038/s41467-019-09908-1
M3 - Article
C2 - 31064987
AN - SCOPUS:85065319026
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 1985
ER -