TY - JOUR
T1 - Remote Control of T Cell Activation Using Magnetic Janus Particles
AU - Lee, Kwahun
AU - Yi, Yi
AU - Yu, Yan
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2016/6/20
Y1 - 2016/6/20
N2 - We report a strategy for using magnetic Janus microparticles to control the stimulation of T cell signaling with single-cell precision. To achieve this, we designed Janus particles that are magnetically responsive on one hemisphere and stimulatory to T cells on the other side. By manipulating the rotation and locomotion of Janus particles under an external magnetic field, we could control the orientation of the particle–cell recognition and thereby the initiation of T cell activation. This study demonstrates a step towards employing anisotropic material properties of Janus particles to control single-cell activities without the need of complex magnetic manipulation devices.
AB - We report a strategy for using magnetic Janus microparticles to control the stimulation of T cell signaling with single-cell precision. To achieve this, we designed Janus particles that are magnetically responsive on one hemisphere and stimulatory to T cells on the other side. By manipulating the rotation and locomotion of Janus particles under an external magnetic field, we could control the orientation of the particle–cell recognition and thereby the initiation of T cell activation. This study demonstrates a step towards employing anisotropic material properties of Janus particles to control single-cell activities without the need of complex magnetic manipulation devices.
KW - Janus particles
KW - colloids
KW - immunology
KW - magnetic properties
KW - nanotechnology
UR - http://www.scopus.com/inward/record.url?scp=84992307757&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992307757&partnerID=8YFLogxK
U2 - 10.1002/anie.201601211
DO - 10.1002/anie.201601211
M3 - Article
C2 - 27144475
AN - SCOPUS:84992307757
SN - 1433-7851
VL - 55
SP - 7384
EP - 7387
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 26
ER -