Remote Control of T Cell Activation Using Magnetic Janus Particles

Kwahun Lee, Yi Yi, Yan Yu

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

We report a strategy for using magnetic Janus microparticles to control the stimulation of T cell signaling with single-cell precision. To achieve this, we designed Janus particles that are magnetically responsive on one hemisphere and stimulatory to T cells on the other side. By manipulating the rotation and locomotion of Janus particles under an external magnetic field, we could control the orientation of the particle–cell recognition and thereby the initiation of T cell activation. This study demonstrates a step towards employing anisotropic material properties of Janus particles to control single-cell activities without the need of complex magnetic manipulation devices.

Original languageEnglish
Pages (from-to)7384-7387
Number of pages4
JournalAngewandte Chemie - International Edition
Volume55
Issue number26
DOIs
StatePublished - 20 Jun 2016

Keywords

  • Janus particles
  • colloids
  • immunology
  • magnetic properties
  • nanotechnology

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