Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer

David D. Bowtell; Steffen Böhm; Ahmed A. Ahmed; Paul Joseph Aspuria; Robert C. Bast; Valerie Beral; Jonathan S. Berek; Michael J. Birrer; Sarah Blagden; Michael A. Bookman; James D. Brenton; Katherine B. Chiappinelli; Filipe Correia Martins; George Coukos; Ronny Drapkin; Richard Edmondson; Christina Fotopoulou; Hani Gabra; Jérôme Galon; Charlie Gourley; Valerie Heong; David G. Huntsman; Marcin Iwanicki; Beth Y. Karlan; Allyson Kaye; Ernst Lengyel; Douglas A. Levine; Karen H. Lu; Iain A. McNeish; Usha Menon; Steven A. Narod; Brad H. Nelson; Kenneth P. Nephew; Paul Pharoah; Daniel J. Powell; Pilar Ramos; Iris L. Romero; Clare L. Scott; Anil K. Sood; Euan A. Stronach; Frances R. Balkwill

doi:10.1038/nrc4019

Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer

David D. Bowtell
, Steffen Böhm
, Ahmed A. Ahmed
, Paul Joseph Aspuria
, Robert C. Bast
, Valerie Beral
, Jonathan S. Berek
, Michael J. Birrer
, Sarah Blagden
, Michael A. Bookman
, James D. Brenton
, Katherine B. Chiappinelli
, Filipe Correia Martins
, George Coukos
, Ronny Drapkin
, Richard Edmondson
, Christina Fotopoulou
, Hani Gabra
, Jérôme Galon
, Charlie Gourley

Valerie Heong, David G. Huntsman, Marcin Iwanicki, Beth Y. Karlan, Allyson Kaye, Ernst Lengyel, Douglas A. Levine, Karen H. Lu, Iain A. McNeish, Usha Menon, Steven A. Narod, Brad H. Nelson, Kenneth P. Nephew, Paul Pharoah, Daniel J. Powell, Pilar Ramos, Iris L. Romero, Clare L. Scott, Anil K. Sood, Euan A. Stronach, Frances R. Balkwill

Peter Maccallum Cancer Centre
Garvan Institute of Medical Research
Queen Mary University of London
Cedars-Sinai Medical Center
University of Texas MD Anderson Cancer Center
University of Oxford
Stanford University
Massachusetts General Hospital
Imperial College London
University of Cambridge
Johns Hopkins University
University of Lausanne
University of Pennsylvania
University of Manchester
Institut national de la santé et de la recherche médicale
University of Edinburgh
Walter and Eliza Hall Institute of Medical Research
University of British Columbia
The University of Chicago
Memorial Sloan-Kettering Cancer Center
University of Glasgow
University College London
University of Toronto
Provincial Health Services Authority
Indiana University Bloomington
Translational Genomics Research Institute

Research output: Contribution to journal › Review article › peer-review

968 Scopus citations

Abstract

High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with this disease. This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015.

Original language	English
Pages (from-to)	668-679
Number of pages	12
Journal	Nature Reviews Cancer
Volume	15
Issue number	11
DOIs	https://doi.org/10.1038/nrc4019
State	Published - 23 Oct 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/nrc4019

Cite this

Bowtell, D. D., Böhm, S., Ahmed, A. A., Aspuria, P. J., Bast, R. C., Beral, V., Berek, J. S., Birrer, M. J., Blagden, S., Bookman, M. A., Brenton, J. D., Chiappinelli, K. B., Martins, F. C., Coukos, G., Drapkin, R., Edmondson, R., Fotopoulou, C., Gabra, H., Galon, J., ... Balkwill, F. R. (2015). Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer. Nature Reviews Cancer, 15(11), 668-679. https://doi.org/10.1038/nrc4019

@article{6b4b833c11ac4908994da4cb93f863de,

title = "Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer",

abstract = "High-grade serous ovarian cancer (HGSOC) accounts for 70-80\% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with this disease. This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015.",

author = "Bowtell, \{David D.\} and Steffen B{\"o}hm and Ahmed, \{Ahmed A.\} and Aspuria, \{Paul Joseph\} and Bast, \{Robert C.\} and Valerie Beral and Berek, \{Jonathan S.\} and Birrer, \{Michael J.\} and Sarah Blagden and Bookman, \{Michael A.\} and Brenton, \{James D.\} and Chiappinelli, \{Katherine B.\} and Martins, \{Filipe Correia\} and George Coukos and Ronny Drapkin and Richard Edmondson and Christina Fotopoulou and Hani Gabra and J{\'e}r{\^o}me Galon and Charlie Gourley and Valerie Heong and Huntsman, \{David G.\} and Marcin Iwanicki and Karlan, \{Beth Y.\} and Allyson Kaye and Ernst Lengyel and Levine, \{Douglas A.\} and Lu, \{Karen H.\} and McNeish, \{Iain A.\} and Usha Menon and Narod, \{Steven A.\} and Nelson, \{Brad H.\} and Nephew, \{Kenneth P.\} and Paul Pharoah and Powell, \{Daniel J.\} and Pilar Ramos and Romero, \{Iris L.\} and Scott, \{Clare L.\} and Sood, \{Anil K.\} and Stronach, \{Euan A.\} and Balkwill, \{Frances R.\}",

year = "2015",

month = oct,

day = "23",

doi = "10.1038/nrc4019",

language = "English",

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Bowtell, DD, Böhm, S, Ahmed, AA, Aspuria, PJ, Bast, RC, Beral, V, Berek, JS, Birrer, MJ, Blagden, S, Bookman, MA, Brenton, JD, Chiappinelli, KB, Martins, FC, Coukos, G, Drapkin, R, Edmondson, R, Fotopoulou, C, Gabra, H, Galon, J, Gourley, C, Heong, V, Huntsman, DG, Iwanicki, M, Karlan, BY, Kaye, A, Lengyel, E, Levine, DA, Lu, KH, McNeish, IA, Menon, U, Narod, SA, Nelson, BH, Nephew, KP, Pharoah, P, Powell, DJ, Ramos, P, Romero, IL, Scott, CL, Sood, AK, Stronach, EA & Balkwill, FR 2015, 'Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer', Nature Reviews Cancer, vol. 15, no. 11, pp. 668-679. https://doi.org/10.1038/nrc4019

TY - JOUR

T1 - Rethinking ovarian cancer II

T2 - Reducing mortality from high-grade serous ovarian cancer

AU - Bowtell, David D.

AU - Böhm, Steffen

AU - Ahmed, Ahmed A.

AU - Aspuria, Paul Joseph

AU - Bast, Robert C.

AU - Beral, Valerie

AU - Berek, Jonathan S.

AU - Birrer, Michael J.

AU - Blagden, Sarah

AU - Bookman, Michael A.

AU - Brenton, James D.

AU - Chiappinelli, Katherine B.

AU - Martins, Filipe Correia

AU - Coukos, George

AU - Drapkin, Ronny

AU - Edmondson, Richard

AU - Fotopoulou, Christina

AU - Gabra, Hani

AU - Galon, Jérôme

AU - Gourley, Charlie

AU - Heong, Valerie

AU - Huntsman, David G.

AU - Iwanicki, Marcin

AU - Karlan, Beth Y.

AU - Kaye, Allyson

AU - Lengyel, Ernst

AU - Levine, Douglas A.

AU - Lu, Karen H.

AU - McNeish, Iain A.

AU - Menon, Usha

AU - Narod, Steven A.

AU - Nelson, Brad H.

AU - Nephew, Kenneth P.

AU - Pharoah, Paul

AU - Powell, Daniel J.

AU - Ramos, Pilar

AU - Romero, Iris L.

AU - Scott, Clare L.

AU - Sood, Anil K.

AU - Stronach, Euan A.

AU - Balkwill, Frances R.

PY - 2015/10/23

Y1 - 2015/10/23

N2 - High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with this disease. This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015.

AB - High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with this disease. This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015.

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U2 - 10.1038/nrc4019

DO - 10.1038/nrc4019

M3 - Review article

C2 - 26493647

AN - SCOPUS:84944871061

SN - 1474-175X

VL - 15

SP - 668

EP - 679

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 11

ER -

Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer

Abstract

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