TY - JOUR
T1 - Retrieval of the physiological state of human skin from UV-Vis reflectance spectra - A feasibility study
AU - Nielsen, K. P.
AU - Zhao, L.
AU - Ryzhikov, G. A.
AU - Biryulina, M. S.
AU - Sommersten, E. R.
AU - Stamnes, J. J.
AU - Stamnes, K.
AU - Moan, J.
PY - 2008/10/16
Y1 - 2008/10/16
N2 - We test the feasibility of using an accurate radiative transfer model for the coupled air-tissue system in conjunction with a classic inversion scheme based on Bayesian optimal estimation theory for retrieval of parameters describing the physiological state of human skin. To that end, we analyse ultraviolet and visible reflectance spectra from human skin measured before, immediately after, and on each day for two weeks after photodynamic treatment with the hexyl ester of ALA and exposure to red light (632 nm). For the first time, we show that it is possible to perform a simultaneous retrieval of the melanosome concentration in both the basal and the upper layers of the epidermis.
AB - We test the feasibility of using an accurate radiative transfer model for the coupled air-tissue system in conjunction with a classic inversion scheme based on Bayesian optimal estimation theory for retrieval of parameters describing the physiological state of human skin. To that end, we analyse ultraviolet and visible reflectance spectra from human skin measured before, immediately after, and on each day for two weeks after photodynamic treatment with the hexyl ester of ALA and exposure to red light (632 nm). For the first time, we show that it is possible to perform a simultaneous retrieval of the melanosome concentration in both the basal and the upper layers of the epidermis.
KW - Numerical simulation
KW - Optical radiation
KW - Radiative transfer
UR - http://www.scopus.com/inward/record.url?scp=52749090148&partnerID=8YFLogxK
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U2 - 10.1016/j.jphotobiol.2008.06.010
DO - 10.1016/j.jphotobiol.2008.06.010
M3 - Article
C2 - 18682328
AN - SCOPUS:52749090148
SN - 1011-1344
VL - 93
SP - 23
EP - 31
JO - Journal of Photochemistry and Photobiology B: Biology
JF - Journal of Photochemistry and Photobiology B: Biology
IS - 1
ER -