TY - JOUR
T1 - Review of Recent Advances and Their Improvement in the Effectiveness of Hydrogel-Based Targeted Drug Delivery
T2 - A Hope for Treating Cancer
AU - Sonker, Muskan
AU - Bajpai, Sushant
AU - Khan, Mohd Ashhar
AU - Yu, Xiaojun
AU - Tiwary, Saurabh Kr
AU - Shreyash, Nehil
N1 - Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/12/20
Y1 - 2021/12/20
N2 - Using hydrogels for delivering cancer therapeutics is advantageous in pharmaceutical usage as they have an edge over traditional delivery, which is tainted due to the risk of toxicity that it imbues. Hydrogel usage leads to the development of a more controlled drug release system owing to its amenability for structural metamorphosis, its higher porosity to seat the drug molecules, and its ability to shield the drug from denaturation. The thing that makes its utility even more enhanced is that they make themselves more recognizable to the body tissues and hence can stay inside the body for a longer time, enhancing the efficiency of the delivery, which otherwise is negatively affected since the drug is identified by the human immunity as a foreign substance, and thus, an attack of the immunity begins on the drug injected. A variety of hydrogels such as thermosensitive, pH-sensitive, and magnetism-responsive hydrogels have been included and their potential usage in drug delivery has been discussed in this review that aims to present recent studies on hydrogels that respond to alterations under a variety of circumstances in "reducing"situations that mimic the microenvironment of cancerous cells.
AB - Using hydrogels for delivering cancer therapeutics is advantageous in pharmaceutical usage as they have an edge over traditional delivery, which is tainted due to the risk of toxicity that it imbues. Hydrogel usage leads to the development of a more controlled drug release system owing to its amenability for structural metamorphosis, its higher porosity to seat the drug molecules, and its ability to shield the drug from denaturation. The thing that makes its utility even more enhanced is that they make themselves more recognizable to the body tissues and hence can stay inside the body for a longer time, enhancing the efficiency of the delivery, which otherwise is negatively affected since the drug is identified by the human immunity as a foreign substance, and thus, an attack of the immunity begins on the drug injected. A variety of hydrogels such as thermosensitive, pH-sensitive, and magnetism-responsive hydrogels have been included and their potential usage in drug delivery has been discussed in this review that aims to present recent studies on hydrogels that respond to alterations under a variety of circumstances in "reducing"situations that mimic the microenvironment of cancerous cells.
KW - Bio-inspired hydrogels
KW - Cancer therapeutics
KW - Doxorubicin
KW - Drug delivery
KW - Hydrogel nanocomposites
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U2 - 10.1021/acsabm.1c00857
DO - 10.1021/acsabm.1c00857
M3 - Review article
C2 - 35005919
AN - SCOPUS:85119415720
VL - 4
SP - 8080
EP - 8109
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 12
ER -