Review of Recent Advances and Their Improvement in the Effectiveness of Hydrogel-Based Targeted Drug Delivery: A Hope for Treating Cancer

Muskan Sonker, Sushant Bajpai, Mohd Ashhar Khan, Xiaojun Yu, Saurabh Kr Tiwary, Nehil Shreyash

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Using hydrogels for delivering cancer therapeutics is advantageous in pharmaceutical usage as they have an edge over traditional delivery, which is tainted due to the risk of toxicity that it imbues. Hydrogel usage leads to the development of a more controlled drug release system owing to its amenability for structural metamorphosis, its higher porosity to seat the drug molecules, and its ability to shield the drug from denaturation. The thing that makes its utility even more enhanced is that they make themselves more recognizable to the body tissues and hence can stay inside the body for a longer time, enhancing the efficiency of the delivery, which otherwise is negatively affected since the drug is identified by the human immunity as a foreign substance, and thus, an attack of the immunity begins on the drug injected. A variety of hydrogels such as thermosensitive, pH-sensitive, and magnetism-responsive hydrogels have been included and their potential usage in drug delivery has been discussed in this review that aims to present recent studies on hydrogels that respond to alterations under a variety of circumstances in "reducing"situations that mimic the microenvironment of cancerous cells.

Original languageEnglish
Pages (from-to)8080-8109
Number of pages30
JournalACS Applied Bio Materials
Volume4
Issue number12
DOIs
StatePublished - 20 Dec 2021

Keywords

  • Bio-inspired hydrogels
  • Cancer therapeutics
  • Doxorubicin
  • Drug delivery
  • Hydrogel nanocomposites

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