TY - JOUR
T1 - Self-Reporting Gold Nanourchins for Tumor-Targeted Chemo-Photothermal Therapy Integrated with Multimodal Imaging
AU - Zhang, Beilu
AU - Wang, Jinping
AU - Sun, Jingyu
AU - Wang, Yuhao
AU - Chou, Tsengming
AU - Zhang, Qiang
AU - Shah, Harshal R.
AU - Ren, Lei
AU - Wang, Hongjun
N1 - Publisher Copyright:
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/10/1
Y1 - 2020/10/1
N2 - In search of facile yet efficient therapeutic and imaging nanoagents for cancer treatment, versatile self-reporting gold nanourchins (AuNUs) featuring synergic chemo-photothermal therapies and multimodal imaging are fabricated. AuNUs are synthesized using a surfactant-free approach, and then functionalized with a Raman reporter 4-mercaptophenylboronic acid (4-MPBA) and dopamine to form adenosine triphosphate (ATP)-cleavable boronate ester bonds prior to further immobilization with hyaluronic acid (HA) for cancer targeting. Controlled release of an anticancer drug, doxorubicin (DOX), loaded in the interstices of AuNUs, is achieved upon exposure to the overproduced hyaluronidase (HAase) in a tumor microenvironment. The spiny exterior of AuNUs enables their optophysical conversion of near-infrared (NIR) light (808 nm) to heat for photothermal therapy and IR imaging. The surface enhanced Raman scattering (SERS) of AuNUs also allows sensitive and reliable Raman mapping of their cellular uptake in vitro, and intratumoral accumulation in vivo, complementary to conventional photoacoustic imaging (PAI). With a demonstrated ability to eradicate tumors and enable multimodal imaging, AuNUs exemplify ongoing efforts in design and utility of multifunctional nanoplatforms.
AB - In search of facile yet efficient therapeutic and imaging nanoagents for cancer treatment, versatile self-reporting gold nanourchins (AuNUs) featuring synergic chemo-photothermal therapies and multimodal imaging are fabricated. AuNUs are synthesized using a surfactant-free approach, and then functionalized with a Raman reporter 4-mercaptophenylboronic acid (4-MPBA) and dopamine to form adenosine triphosphate (ATP)-cleavable boronate ester bonds prior to further immobilization with hyaluronic acid (HA) for cancer targeting. Controlled release of an anticancer drug, doxorubicin (DOX), loaded in the interstices of AuNUs, is achieved upon exposure to the overproduced hyaluronidase (HAase) in a tumor microenvironment. The spiny exterior of AuNUs enables their optophysical conversion of near-infrared (NIR) light (808 nm) to heat for photothermal therapy and IR imaging. The surface enhanced Raman scattering (SERS) of AuNUs also allows sensitive and reliable Raman mapping of their cellular uptake in vitro, and intratumoral accumulation in vivo, complementary to conventional photoacoustic imaging (PAI). With a demonstrated ability to eradicate tumors and enable multimodal imaging, AuNUs exemplify ongoing efforts in design and utility of multifunctional nanoplatforms.
KW - Raman imaging
KW - chemotherapy
KW - controlled drug release
KW - photoacoustic imaging
KW - photothermal therapy
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U2 - 10.1002/adtp.202000114
DO - 10.1002/adtp.202000114
M3 - Article
AN - SCOPUS:85103744061
VL - 3
JO - Advanced Therapeutics
JF - Advanced Therapeutics
IS - 10
M1 - 2000114
ER -