TY - JOUR
T1 - Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis
AU - Engen, Phillip A.
AU - Zaferiou, Antonia
AU - Rasmussen, Heather
AU - Naqib, Ankur
AU - Green, Stefan J.
AU - Fogg, Louis F.
AU - Forsyth, Christopher B.
AU - Raeisi, Shohreh
AU - Hamaker, Bruce
AU - Keshavarzian, Ali
N1 - Publisher Copyright:
© Copyright © 2020 Engen, Zaferiou, Rasmussen, Naqib, Green, Fogg, Forsyth, Raeisi, Hamaker and Keshavarzian.
PY - 2020/9/8
Y1 - 2020/9/8
N2 - Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated the impact of fecal-microbiota-transplantation (FMT) on a broad array of physiological/clinical outcomes using deep metagenome sequencing of fecal microbiome. FMT interventions were associated with increased abundances of putative beneficial stool bacteria and short-chain-fatty-acid metabolites, which were associated with increased/improved serum brain-derived-neurotrophic-factor levels and gait/walking metrics. This proof-of-concept single-subject longitudinal study provides evidence of potential importance of intestinal microbiota in the pathogenesis of MS, and scientific rationale to help design future randomized controlled trials assessing FMT in RRMS patients.
AB - Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated the impact of fecal-microbiota-transplantation (FMT) on a broad array of physiological/clinical outcomes using deep metagenome sequencing of fecal microbiome. FMT interventions were associated with increased abundances of putative beneficial stool bacteria and short-chain-fatty-acid metabolites, which were associated with increased/improved serum brain-derived-neurotrophic-factor levels and gait/walking metrics. This proof-of-concept single-subject longitudinal study provides evidence of potential importance of intestinal microbiota in the pathogenesis of MS, and scientific rationale to help design future randomized controlled trials assessing FMT in RRMS patients.
KW - brain-derived neurotrophic factor
KW - fecal microbiota transplantation
KW - gait
KW - metabolomics
KW - microbiome
KW - multiple sclerosis
KW - relapsing-remitting multiple sclerosis
KW - short-chain fatty acids
UR - http://www.scopus.com/inward/record.url?scp=85091465346&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85091465346&partnerID=8YFLogxK
U2 - 10.3389/fneur.2020.00978
DO - 10.3389/fneur.2020.00978
M3 - Article
AN - SCOPUS:85091465346
VL - 11
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 978
ER -