TY - JOUR
T1 - Stabilizing electrode-host interfaces
T2 - A tissue engineering approach
AU - Zhong, Yinghui
AU - Yu, Xiaojun
AU - Gilbert, Ryan
AU - Bellamkonda, Ravi V.
PY - 2001
Y1 - 2001
N2 - The stability of implanted electrodes is a significant problem affecting their long-term use in vivo. Problems include mechanical failure and inflammation at the implantation site. The engineering of bioactive electrode coatings has been investigated for its potential to promote in-growth of neural tissue and reduce sheer at the electrode-host interface. Preliminary results indicate that hydrogel coatings with either collagen I or polylysine-laminin-1 can promote cortical nerve cell attachment and differentiation on silicon substrates. Additionally, slow-release microtubules can also be implanted in these gels to release agents that either provide trophic support to neurons or prevent inflammation locally. When silicon discs are coated with collagen type I, the coating remains stable for 55 days. Further testing is underway, but initial results indicate that tissue-engineering approaches provide useful insights to help address the problem of host-electrode instability in the brain.
AB - The stability of implanted electrodes is a significant problem affecting their long-term use in vivo. Problems include mechanical failure and inflammation at the implantation site. The engineering of bioactive electrode coatings has been investigated for its potential to promote in-growth of neural tissue and reduce sheer at the electrode-host interface. Preliminary results indicate that hydrogel coatings with either collagen I or polylysine-laminin-1 can promote cortical nerve cell attachment and differentiation on silicon substrates. Additionally, slow-release microtubules can also be implanted in these gels to release agents that either provide trophic support to neurons or prevent inflammation locally. When silicon discs are coated with collagen type I, the coating remains stable for 55 days. Further testing is underway, but initial results indicate that tissue-engineering approaches provide useful insights to help address the problem of host-electrode instability in the brain.
KW - Biomaterials
KW - Drug delivery
KW - Electrode coatings
KW - FES
KW - Hydrogels
KW - Neural tissue engineering
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M3 - Article
C2 - 11767970
AN - SCOPUS:0035706178
SN - 0748-7711
VL - 38
SP - 627
EP - 632
JO - Journal of Rehabilitation Research and Development
JF - Journal of Rehabilitation Research and Development
IS - 6
ER -