TY - JOUR
T1 - Strategies in the design of gold nanoparticles for intracellular targeting
T2 - Opportunities and challenges
AU - Yang, Yamin
AU - Ren, Lei
AU - Wang, Hongjun
N1 - Publisher Copyright:
© 2017 2017 Future Science Ltd.
PY - 2017/10
Y1 - 2017/10
N2 - With unique physicochemical properties, gold nanoparticles (Au NPs) have demonstrated their potential as drug carriers or therapeutic agents. Effective guidance of Au NPs into specific intracellular destinations becomes increasingly important as we strive to further improve the efficiency of drug delivery and modulate controllable cellular responses. In this review, we summarized recent advances in designing Au NPs with the capabilities of cellular penetration and internalization, endosomal escape, intracellular trafficking and subcellular localization via various approaches including physical injection, tuning the physiochemical parameters of Au NPs, and surface modification with targeting ligands. Strategies for delivering Au NPs to specific subcellular destinations including the nucleus, mitochondria, endoplasmic reticulum, lysosomes are also discussed. Moreover, current challenges associated with intracellular targeting of Au NPs are discussed with future perspectives proposed.
AB - With unique physicochemical properties, gold nanoparticles (Au NPs) have demonstrated their potential as drug carriers or therapeutic agents. Effective guidance of Au NPs into specific intracellular destinations becomes increasingly important as we strive to further improve the efficiency of drug delivery and modulate controllable cellular responses. In this review, we summarized recent advances in designing Au NPs with the capabilities of cellular penetration and internalization, endosomal escape, intracellular trafficking and subcellular localization via various approaches including physical injection, tuning the physiochemical parameters of Au NPs, and surface modification with targeting ligands. Strategies for delivering Au NPs to specific subcellular destinations including the nucleus, mitochondria, endoplasmic reticulum, lysosomes are also discussed. Moreover, current challenges associated with intracellular targeting of Au NPs are discussed with future perspectives proposed.
KW - gold nanoparticles
KW - intracellular targeting
KW - subcellular organelles
KW - surface modification
UR - http://www.scopus.com/inward/record.url?scp=85029947493&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029947493&partnerID=8YFLogxK
U2 - 10.4155/tde-2017-0049
DO - 10.4155/tde-2017-0049
M3 - Review article
C2 - 28944735
AN - SCOPUS:85029947493
SN - 2041-5990
VL - 8
SP - 879
EP - 897
JO - Therapeutic Delivery
JF - Therapeutic Delivery
IS - 10
ER -