Structural optimization of cyclic sulfonamide based novel HIV-1 protease inhibitors to picomolar affinities guided by X-ray crystallographic analysis

Ashit K. Ganguly, Sesha S. Alluri, Chih Hung Wang, Alyssa Antropow, Alex White, Danielle Caroccia, Dipshikha Biswas, Eunhee Kang, Li Kang Zhang, Steven S. Carroll, Christine Burlein, John Fay, Peter Orth, Corey Strickland

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Biochemistry, Genetics and Molecular Biology