Substituted 2-ammopyridines as inhibitors of nitric oxide synthases

William K. Hagmann, Charles G. Caldwell, Ping Chen, Philippe L. Durette, Craig K. Esser, Thomas J. Lanza, Ihor E. Kopka, Ravi Guthikonda, Shrenik K. Shah, Malcolm MacCoss, Renee M. Chabin, Daniel Fletcher, Stephan K. Grant, Barbara G. Green, John L. Humes, Theresa M. Kelly, Sylvie Luell, Roger Meurer, Vernon Moore, Stephen G. PacholokTony Pavia, Hollis R. Williams, Kenny K. Wong

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)1975-1978
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number17
DOIs
StatePublished - 4 Sep 2000

Fingerprint

Dive into the research topics of 'Substituted 2-ammopyridines as inhibitors of nitric oxide synthases'. Together they form a unique fingerprint.

Cite this