TY - JOUR
T1 - Substituted 2-ammopyridines as inhibitors of nitric oxide synthases
AU - Hagmann, William K.
AU - Caldwell, Charles G.
AU - Chen, Ping
AU - Durette, Philippe L.
AU - Esser, Craig K.
AU - Lanza, Thomas J.
AU - Kopka, Ihor E.
AU - Guthikonda, Ravi
AU - Shah, Shrenik K.
AU - MacCoss, Malcolm
AU - Chabin, Renee M.
AU - Fletcher, Daniel
AU - Grant, Stephan K.
AU - Green, Barbara G.
AU - Humes, John L.
AU - Kelly, Theresa M.
AU - Luell, Sylvie
AU - Meurer, Roger
AU - Moore, Vernon
AU - Pacholok, Stephen G.
AU - Pavia, Tony
AU - Williams, Hollis R.
AU - Wong, Kenny K.
PY - 2000/9/4
Y1 - 2000/9/4
N2 - A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM. (C) 2000 Elsevier Science Ltd.
AB - A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM. (C) 2000 Elsevier Science Ltd.
UR - https://www.scopus.com/pages/publications/0034604846
UR - https://www.scopus.com/pages/publications/0034604846#tab=citedBy
U2 - 10.1016/S0960-894X(00)00389-9
DO - 10.1016/S0960-894X(00)00389-9
M3 - Article
C2 - 10987430
AN - SCOPUS:0034604846
SN - 0960-894X
VL - 10
SP - 1975
EP - 1978
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 17
ER -