Synthesis of deuterium labeled polyunsaturated fatty acids

Aleš Svatoš; Athula B. Attygalle; Jerrold Meinwald

doi:10.1016/0040-4039(94)88495-1

Synthesis of deuterium labeled polyunsaturated fatty acids

Aleš Svatoš
, Athula B. Attygalle
, Jerrold Meinwald

Department of Chemistry and Chemical Biology

Cornell University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Compounds containing carbon-carbon double bonds bearing cis deuterium atoms can be prepared conveniently by treating disubstituted acetylenes with bis(2-deuteriocyclohexyl)borane-B-D₁ [DB(Cy)₂] followed by reaction with CH₃CO₂D. As an example, the preparation of labeled linolenic acid is reported.

Original language	English
Pages (from-to)	9497-9500
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	51
DOIs	https://doi.org/10.1016/0040-4039(94)88495-1
State	Published - 19 Dec 1994

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@article{b3e48fb9fbc24ff98d65ca6f4291017a,

title = "Synthesis of deuterium labeled polyunsaturated fatty acids",

abstract = "Compounds containing carbon-carbon double bonds bearing cis deuterium atoms can be prepared conveniently by treating disubstituted acetylenes with bis(2-deuteriocyclohexyl)borane-B-D1 [DB(Cy)2] followed by reaction with CH3CO2D. As an example, the preparation of labeled linolenic acid is reported.",

author = "Ale{\v s} Svato{\v s} and Attygalle, \{Athula B.\} and Jerrold Meinwald",

year = "1994",

month = dec,

day = "19",

doi = "10.1016/0040-4039(94)88495-1",

language = "English",

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T1 - Synthesis of deuterium labeled polyunsaturated fatty acids

AU - Svatoš, Aleš

AU - Attygalle, Athula B.

AU - Meinwald, Jerrold

PY - 1994/12/19

Y1 - 1994/12/19

N2 - Compounds containing carbon-carbon double bonds bearing cis deuterium atoms can be prepared conveniently by treating disubstituted acetylenes with bis(2-deuteriocyclohexyl)borane-B-D1 [DB(Cy)2] followed by reaction with CH3CO2D. As an example, the preparation of labeled linolenic acid is reported.

AB - Compounds containing carbon-carbon double bonds bearing cis deuterium atoms can be prepared conveniently by treating disubstituted acetylenes with bis(2-deuteriocyclohexyl)borane-B-D1 [DB(Cy)2] followed by reaction with CH3CO2D. As an example, the preparation of labeled linolenic acid is reported.

UR - https://www.scopus.com/pages/publications/0028034127

UR - https://www.scopus.com/pages/publications/0028034127#tab=citedBy

U2 - 10.1016/0040-4039(94)88495-1

DO - 10.1016/0040-4039(94)88495-1

M3 - Article

AN - SCOPUS:0028034127

SN - 0040-4039

VL - 35

SP - 9497

EP - 9500

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 51

ER -

Synthesis of deuterium labeled polyunsaturated fatty acids

Abstract

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