TY - JOUR
T1 - Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell killing activity
AU - Liang, Jun F.
AU - Yang, Victor C.
PY - 2005/11/15
Y1 - 2005/11/15
N2 - Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin-TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.
AB - Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin-TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.
KW - Anticancer drug
KW - Cell penetrating peptide
KW - Conjugates
KW - Drug resistance
KW - P-glycoprotein
KW - Tumor
UR - http://www.scopus.com/inward/record.url?scp=25844511216&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=25844511216&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2005.07.087
DO - 10.1016/j.bmcl.2005.07.087
M3 - Article
C2 - 16168650
AN - SCOPUS:25844511216
SN - 0960-894X
VL - 15
SP - 5071
EP - 5075
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 22
ER -