Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell killing activity

Jun F. Liang, Victor C. Yang

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin-TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.

Original languageEnglish
Pages (from-to)5071-5075
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number22
DOIs
StatePublished - 15 Nov 2005

Keywords

  • Anticancer drug
  • Cell penetrating peptide
  • Conjugates
  • Drug resistance
  • P-glycoprotein
  • Tumor

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