Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell killing activity

Jun F. Liang; Victor C. Yang

doi:10.1016/j.bmcl.2005.07.087

Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell killing activity

Jun F. Liang, Victor C. Yang

Department of Chemistry and Chemical Biology

University of Michigan, Ann Arbor

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin-TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.

Original language	English
Pages (from-to)	5071-5075
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2005.07.087
State	Published - 15 Nov 2005

Keywords

Anticancer drug
Cell penetrating peptide
Conjugates
Drug resistance
P-glycoprotein
Tumor

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10.1016/j.bmcl.2005.07.087

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title = "Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell killing activity",

abstract = "Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin-TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.",

keywords = "Anticancer drug, Cell penetrating peptide, Conjugates, Drug resistance, P-glycoprotein, Tumor",

author = "Liang, \{Jun F.\} and Yang, \{Victor C.\}",

year = "2005",

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language = "English",

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T1 - Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell killing activity

AU - Liang, Jun F.

AU - Yang, Victor C.

PY - 2005/11/15

Y1 - 2005/11/15

N2 - Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin-TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.

AB - Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin-TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.

KW - Anticancer drug

KW - Cell penetrating peptide

KW - Conjugates

KW - Drug resistance

KW - P-glycoprotein

KW - Tumor

UR - https://www.scopus.com/pages/publications/25844511216

UR - https://www.scopus.com/inward/citedby.url?scp=25844511216&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2005.07.087

DO - 10.1016/j.bmcl.2005.07.087

M3 - Article

C2 - 16168650

AN - SCOPUS:25844511216

SN - 0960-894X

VL - 15

SP - 5071

EP - 5075

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 22

ER -

Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell killing activity

Abstract

Keywords

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