TY - JOUR
T1 - Synthesis of polymeric β-cyclodextrin supported by crosslinked poly(acrylamide-co-vinylamine) and its catalysis of the hydrolysis of p-nitrophenyl acetate
AU - Wang, Hong Jun
AU - Ma, Jian Biao
AU - He, Bing Lin
PY - 2000/3
Y1 - 2000/3
N2 - Polymeric β-cyclodextrin (β-CD) supported by crosslinked poly(acrylamide-co-vinylamine) was synthesized as an artificial analog of hydrolytic enzyme and its catalysis of the hydrolysis of p-nitrophenyl acetate (p-NPA) was then investigated. The result showed that the polymer-supported β-CD could accelerate the hydrolytic reaction of p-NPA more quickly than β-CD itself and crosslinked poly(acrylamide-co-vinylamine) alone. The acceleration rate of the polymer-supported β-CD was about 10 times as fast as that of free β-CD in 0.01 mol/L phosphate buffer (pH 7.4) containing 32% DMSO at 37±0.1°C when the molar amount of β-CD units in the polymer was equal to that of free β-CD in the experiments. The enhanced acceleration of the polymer-supported β-CD should be ascribed to the cooperative contribution of the inclusion effect of β-CD ring and the nucleophilic effect of amino groups on the polymeric support.
AB - Polymeric β-cyclodextrin (β-CD) supported by crosslinked poly(acrylamide-co-vinylamine) was synthesized as an artificial analog of hydrolytic enzyme and its catalysis of the hydrolysis of p-nitrophenyl acetate (p-NPA) was then investigated. The result showed that the polymer-supported β-CD could accelerate the hydrolytic reaction of p-NPA more quickly than β-CD itself and crosslinked poly(acrylamide-co-vinylamine) alone. The acceleration rate of the polymer-supported β-CD was about 10 times as fast as that of free β-CD in 0.01 mol/L phosphate buffer (pH 7.4) containing 32% DMSO at 37±0.1°C when the molar amount of β-CD units in the polymer was equal to that of free β-CD in the experiments. The enhanced acceleration of the polymer-supported β-CD should be ascribed to the cooperative contribution of the inclusion effect of β-CD ring and the nucleophilic effect of amino groups on the polymeric support.
KW - Crosslinked poly(acrylamide-co-vinylamine)
KW - Hydrolysis of p-nitrophenyl acetate
KW - Polymer-supported catalysis
KW - β-cyclodextrin
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M3 - Article
AN - SCOPUS:0034423120
SN - 0256-7679
VL - 18
SP - 155
EP - 160
JO - Chinese Journal of Polymer Science (English Edition)
JF - Chinese Journal of Polymer Science (English Edition)
IS - 2
ER -