TY - JOUR
T1 - Targeted drug delivery to C6 glioma by transferrin-coupled liposomes
AU - Eavarone, David A.
AU - Yu, Xiaojun
AU - Bellamkonda, Ravi V.
PY - 2000
Y1 - 2000
N2 - A liposomal delivery system was engineered for the chemotherapeutic drug doxorubicin. The system was targeted to C6 glioma in vitro by coupling transferrin to the distal ends of liposomal polyethylene glycol (PEG) chains. Significantly increased gliomal doxorubicin uptake was achieved by drug encapsulation within transferin-coupled liposomes compared to other liposome populations. Competitive binding assays support the receptor-mediated mechanism of targeting.
AB - A liposomal delivery system was engineered for the chemotherapeutic drug doxorubicin. The system was targeted to C6 glioma in vitro by coupling transferrin to the distal ends of liposomal polyethylene glycol (PEG) chains. Significantly increased gliomal doxorubicin uptake was achieved by drug encapsulation within transferin-coupled liposomes compared to other liposome populations. Competitive binding assays support the receptor-mediated mechanism of targeting.
KW - Argeted drug delivery
KW - C6 glioma
KW - Doxorubicin
KW - PEG liposome
KW - Transferrin receptor
UR - http://www.scopus.com/inward/record.url?scp=0034075131&partnerID=8YFLogxK
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U2 - 10.1002/(SICI)1097-4636(200007)51:1<10::AID-JBM2>3.0.CO;2-R
DO - 10.1002/(SICI)1097-4636(200007)51:1<10::AID-JBM2>3.0.CO;2-R
M3 - Article
C2 - 10813739
AN - SCOPUS:0034075131
SN - 0021-9304
VL - 51
SP - 10
EP - 14
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
IS - 1
ER -