Targeted drug delivery to C6 glioma by transferrin-coupled liposomes

David A. Eavarone, Xiaojun Yu, Ravi V. Bellamkonda

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

A liposomal delivery system was engineered for the chemotherapeutic drug doxorubicin. The system was targeted to C6 glioma in vitro by coupling transferrin to the distal ends of liposomal polyethylene glycol (PEG) chains. Significantly increased gliomal doxorubicin uptake was achieved by drug encapsulation within transferin-coupled liposomes compared to other liposome populations. Competitive binding assays support the receptor-mediated mechanism of targeting.

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalJournal of Biomedical Materials Research
Volume51
Issue number1
DOIs
StatePublished - 2000

Keywords

  • Argeted drug delivery
  • C6 glioma
  • Doxorubicin
  • PEG liposome
  • Transferrin receptor

Fingerprint

Dive into the research topics of 'Targeted drug delivery to C6 glioma by transferrin-coupled liposomes'. Together they form a unique fingerprint.

Cite this