The minimal functional sequence of protamine

Jun Feng Liang, Victor C. Yang, Yekaterina Vaynshteyn

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Despite its nearly universal applications, protamine, a mixture of four major peptides with different sequences, is associated with clinically significant side effects. Through a well-designed enzyme digestion method, various low molecular weight protamine peptides were obtained. Among them, two low molecular weight protamine peptides with the same or even more potent heparin neutralization abilities as native protamine were identified through both in vitro and in vivo tests. In addition, in vivo experiments showed that compared to native protamine, these two low molecular weight protamine peptides were less toxic and would be safer for clinical use.

Original languageEnglish
Pages (from-to)653-659
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume336
Issue number2
DOIs
StatePublished - 21 Oct 2005

Keywords

  • Gene delivery
  • Insulin
  • LMWH
  • Peptide
  • Protamine
  • Toxicity

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