Abstract
The O2 reactivity of an artificial biomolecular hydrogenase, the nickel binding protein (NBP) is investigated. Kinetic analyses revealed a complete 4e- reduction of O2 to H2O under catalytic conditions with associated k0 for ET in the order of 10-6 cm s-1. Protein destabilization and S oxygenation are contributing factors to the deactivation of NBP under oxic conditions. Computational studies provided insight into the S oxygenation and the reaction intermediates of a proposed mechanistic pathway for O2 activation by NBP.
Original language | English |
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Pages (from-to) | 1928-1934 |
Number of pages | 7 |
Journal | Dalton Transactions |
Volume | 49 |
Issue number | 6 |
DOIs | |
State | Published - 14 Feb 2020 |