TY - JOUR
T1 - The use of ultra high-performance liquid chromatography for studying hydrolysis kinetics of CL-20 and related energetic compounds
AU - Makarov, Alexey
AU - LoBrutto, Rosario
AU - Christodoulatos, Christos
AU - Jerkovich, Anton
PY - 2009/3/15
Y1 - 2009/3/15
N2 - Ultra high-performance liquid chromatography (UHPLC) utilizes columns packed with sub-2-μm stationary-phase particles and allows operation with pressures of up to 15,000 psi to yield increased resolution, speed, and sensitivity versus conventional HPLC. This promising new technology was used for the analysis of energetic compounds (RDX, HMX and CL-20) and a selective method was developed on an Acquity UPLC™. A fast UHPLC method was applied to determine alkaline hydrolysis reaction kinetics of major energetic compounds. Activation energies of alkaline hydrolysis reaction for CL-20, RDX and HMX were comparable to those in literature, however they were determined in a shorter amount of time due to the speed of analysis of the chromatographic method. The use of liophilic salts (KPF6) as mobile-phase additives for the enhancement of separation selectivity of energetic compounds was demonstrated.
AB - Ultra high-performance liquid chromatography (UHPLC) utilizes columns packed with sub-2-μm stationary-phase particles and allows operation with pressures of up to 15,000 psi to yield increased resolution, speed, and sensitivity versus conventional HPLC. This promising new technology was used for the analysis of energetic compounds (RDX, HMX and CL-20) and a selective method was developed on an Acquity UPLC™. A fast UHPLC method was applied to determine alkaline hydrolysis reaction kinetics of major energetic compounds. Activation energies of alkaline hydrolysis reaction for CL-20, RDX and HMX were comparable to those in literature, however they were determined in a shorter amount of time due to the speed of analysis of the chromatographic method. The use of liophilic salts (KPF6) as mobile-phase additives for the enhancement of separation selectivity of energetic compounds was demonstrated.
KW - CL-20
KW - HMX
KW - Liophilic additives
KW - RDX
KW - UHPLC
UR - http://www.scopus.com/inward/record.url?scp=57749183190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57749183190&partnerID=8YFLogxK
U2 - 10.1016/j.jhazmat.2008.05.157
DO - 10.1016/j.jhazmat.2008.05.157
M3 - Article
C2 - 18644671
AN - SCOPUS:57749183190
SN - 0304-3894
VL - 162
SP - 1034
EP - 1040
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
IS - 2-3
ER -