The use of ultra high-performance liquid chromatography for studying hydrolysis kinetics of CL-20 and related energetic compounds

Alexey Makarov, Rosario LoBrutto, Christos Christodoulatos, Anton Jerkovich

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Ultra high-performance liquid chromatography (UHPLC) utilizes columns packed with sub-2-μm stationary-phase particles and allows operation with pressures of up to 15,000 psi to yield increased resolution, speed, and sensitivity versus conventional HPLC. This promising new technology was used for the analysis of energetic compounds (RDX, HMX and CL-20) and a selective method was developed on an Acquity UPLC™. A fast UHPLC method was applied to determine alkaline hydrolysis reaction kinetics of major energetic compounds. Activation energies of alkaline hydrolysis reaction for CL-20, RDX and HMX were comparable to those in literature, however they were determined in a shorter amount of time due to the speed of analysis of the chromatographic method. The use of liophilic salts (KPF6) as mobile-phase additives for the enhancement of separation selectivity of energetic compounds was demonstrated.

Original languageEnglish
Pages (from-to)1034-1040
Number of pages7
JournalJournal of Hazardous Materials
Volume162
Issue number2-3
DOIs
StatePublished - 15 Mar 2009

Keywords

  • CL-20
  • HMX
  • Liophilic additives
  • RDX
  • UHPLC

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