The use of ultra high-performance liquid chromatography for studying hydrolysis kinetics of CL-20 and related energetic compounds

Alexey Makarov; Rosario LoBrutto; Christos Christodoulatos; Anton Jerkovich

doi:10.1016/j.jhazmat.2008.05.157

The use of ultra high-performance liquid chromatography for studying hydrolysis kinetics of CL-20 and related energetic compounds

Alexey Makarov
, Rosario LoBrutto
, Christos Christodoulatos
, Anton Jerkovich

Department of Civil, Environmental and Ocean Engineering

Novartis

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Ultra high-performance liquid chromatography (UHPLC) utilizes columns packed with sub-2-μm stationary-phase particles and allows operation with pressures of up to 15,000 psi to yield increased resolution, speed, and sensitivity versus conventional HPLC. This promising new technology was used for the analysis of energetic compounds (RDX, HMX and CL-20) and a selective method was developed on an Acquity UPLC™. A fast UHPLC method was applied to determine alkaline hydrolysis reaction kinetics of major energetic compounds. Activation energies of alkaline hydrolysis reaction for CL-20, RDX and HMX were comparable to those in literature, however they were determined in a shorter amount of time due to the speed of analysis of the chromatographic method. The use of liophilic salts (KPF₆) as mobile-phase additives for the enhancement of separation selectivity of energetic compounds was demonstrated.

Original language	English
Pages (from-to)	1034-1040
Number of pages	7
Journal	Journal of Hazardous Materials
Volume	162
Issue number	2-3
DOIs	https://doi.org/10.1016/j.jhazmat.2008.05.157
State	Published - 15 Mar 2009

Keywords

CL-20
HMX
Liophilic additives
RDX
UHPLC

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10.1016/j.jhazmat.2008.05.157

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abstract = "Ultra high-performance liquid chromatography (UHPLC) utilizes columns packed with sub-2-μm stationary-phase particles and allows operation with pressures of up to 15,000 psi to yield increased resolution, speed, and sensitivity versus conventional HPLC. This promising new technology was used for the analysis of energetic compounds (RDX, HMX and CL-20) and a selective method was developed on an Acquity UPLC{\texttrademark}. A fast UHPLC method was applied to determine alkaline hydrolysis reaction kinetics of major energetic compounds. Activation energies of alkaline hydrolysis reaction for CL-20, RDX and HMX were comparable to those in literature, however they were determined in a shorter amount of time due to the speed of analysis of the chromatographic method. The use of liophilic salts (KPF6) as mobile-phase additives for the enhancement of separation selectivity of energetic compounds was demonstrated.",

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AU - Makarov, Alexey

AU - LoBrutto, Rosario

AU - Christodoulatos, Christos

AU - Jerkovich, Anton

PY - 2009/3/15

Y1 - 2009/3/15

N2 - Ultra high-performance liquid chromatography (UHPLC) utilizes columns packed with sub-2-μm stationary-phase particles and allows operation with pressures of up to 15,000 psi to yield increased resolution, speed, and sensitivity versus conventional HPLC. This promising new technology was used for the analysis of energetic compounds (RDX, HMX and CL-20) and a selective method was developed on an Acquity UPLC™. A fast UHPLC method was applied to determine alkaline hydrolysis reaction kinetics of major energetic compounds. Activation energies of alkaline hydrolysis reaction for CL-20, RDX and HMX were comparable to those in literature, however they were determined in a shorter amount of time due to the speed of analysis of the chromatographic method. The use of liophilic salts (KPF6) as mobile-phase additives for the enhancement of separation selectivity of energetic compounds was demonstrated.

AB - Ultra high-performance liquid chromatography (UHPLC) utilizes columns packed with sub-2-μm stationary-phase particles and allows operation with pressures of up to 15,000 psi to yield increased resolution, speed, and sensitivity versus conventional HPLC. This promising new technology was used for the analysis of energetic compounds (RDX, HMX and CL-20) and a selective method was developed on an Acquity UPLC™. A fast UHPLC method was applied to determine alkaline hydrolysis reaction kinetics of major energetic compounds. Activation energies of alkaline hydrolysis reaction for CL-20, RDX and HMX were comparable to those in literature, however they were determined in a shorter amount of time due to the speed of analysis of the chromatographic method. The use of liophilic salts (KPF6) as mobile-phase additives for the enhancement of separation selectivity of energetic compounds was demonstrated.

KW - CL-20

KW - HMX

KW - Liophilic additives

KW - RDX

KW - UHPLC

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JO - Journal of Hazardous Materials

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The use of ultra high-performance liquid chromatography for studying hydrolysis kinetics of CL-20 and related energetic compounds

Abstract

Keywords

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