TY - JOUR
T1 - Thermo-responsive hydrogels for ocular drug delivery
AU - Kang-Mieler, Jennifer J.
AU - Mieler, William F.
N1 - Publisher Copyright:
© 2016 S. Karger AG, Basel.
PY - 2015
Y1 - 2015
N2 - Hydrogel as an ocular drug delivery platform holds great potential. Hydrogels are three-dimensional, hydrophilic, polymeric networks capable of absorbing large amounts of water or biological fluids. They have the ability to swell in an aqueous solvent system, holding solvents within a cross-linked gel system for potential sustained delivery. Through manipulation of permeation and diffusion characteristics, they can retain hydrophobic and hydrophilic agents, small molecules and macromolecules. In addition, hydrogel can be combined with nano- or microspheres to enhance delivery capacity. The aqueous environment of hydrogels can also protect cells and pharmacological agents. Depending on the specific structure, they can be nondegradable or degradable in their application.
AB - Hydrogel as an ocular drug delivery platform holds great potential. Hydrogels are three-dimensional, hydrophilic, polymeric networks capable of absorbing large amounts of water or biological fluids. They have the ability to swell in an aqueous solvent system, holding solvents within a cross-linked gel system for potential sustained delivery. Through manipulation of permeation and diffusion characteristics, they can retain hydrophobic and hydrophilic agents, small molecules and macromolecules. In addition, hydrogel can be combined with nano- or microspheres to enhance delivery capacity. The aqueous environment of hydrogels can also protect cells and pharmacological agents. Depending on the specific structure, they can be nondegradable or degradable in their application.
UR - http://www.scopus.com/inward/record.url?scp=84947218713&partnerID=8YFLogxK
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U2 - 10.1159/000434694
DO - 10.1159/000434694
M3 - Article
C2 - 26502091
AN - SCOPUS:84947218713
SN - 0250-3751
VL - 55
SP - 104
EP - 111
JO - Developments in Ophthalmology
JF - Developments in Ophthalmology
ER -