TY - GEN
T1 - Three-dimensional mapping of corneal elasticity using optical coherence elastography
AU - Singh, Manmohan
AU - Li, Jiasong
AU - Wang, Shang
AU - Vantipalli, Srilatha
AU - Twa, Michael
AU - Larin, Kirill V.
N1 - Publisher Copyright:
© 2015 SPIE.
PY - 2015
Y1 - 2015
N2 - We demonstrate a novel method for noninvasive quantification of tissue biomechanical properties in 3D using phase-stabilized swept source optical coherence elastography (PhS-SSOCE). A focused air-pulse delivery system induces an elastic wave, which is then recorded by the PhS-SSOCE system. By calculating the velocity in all radial directions and imaging depths from the origin of the stimulation, a volumetric elasticity map was generated. Utilizing the high spatial sensitivity of PhS-SSOCE, the force applied on the surface of the cornea and subsequent induced deformation amplitude was minimal, thus preserving the structure and function of delicate ocular tissues such as the cornea and sclera. The results show that this noninvasive method for elasticity assessment can provide a volumetric mapping of elasticity and can differentiate untreated and UV-induced collagen cross-linked (CXL) corneas. As expected, the elastic wave velocity and subsequent Young’s modulus was significantly higher in the CXL cornea as compared to the untreated cornea, indicating a substantial increase in corneal stiffness after the CXL treatment.
AB - We demonstrate a novel method for noninvasive quantification of tissue biomechanical properties in 3D using phase-stabilized swept source optical coherence elastography (PhS-SSOCE). A focused air-pulse delivery system induces an elastic wave, which is then recorded by the PhS-SSOCE system. By calculating the velocity in all radial directions and imaging depths from the origin of the stimulation, a volumetric elasticity map was generated. Utilizing the high spatial sensitivity of PhS-SSOCE, the force applied on the surface of the cornea and subsequent induced deformation amplitude was minimal, thus preserving the structure and function of delicate ocular tissues such as the cornea and sclera. The results show that this noninvasive method for elasticity assessment can provide a volumetric mapping of elasticity and can differentiate untreated and UV-induced collagen cross-linked (CXL) corneas. As expected, the elastic wave velocity and subsequent Young’s modulus was significantly higher in the CXL cornea as compared to the untreated cornea, indicating a substantial increase in corneal stiffness after the CXL treatment.
KW - Optical coherence elastography
KW - collagen cross-linking
KW - cornea
KW - keratoconus
UR - http://www.scopus.com/inward/record.url?scp=84928580003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928580003&partnerID=8YFLogxK
U2 - 10.1117/12.2080066
DO - 10.1117/12.2080066
M3 - Conference contribution
AN - SCOPUS:84928580003
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Ophthalmic Technologies XXV
A2 - Ho, Arthur
A2 - Manns, Fabrice
A2 - Soderberg, Per G.
T2 - 25th Conference on Ophthalmic Technologies
Y2 - 7 February 2015 through 8 February 2015
ER -