Three-dimensional mapping of corneal elasticity using optical coherence elastography

Manmohan Singh, Jiasong Li, Shang Wang, Srilatha Vantipalli, Michael Twa, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We demonstrate a novel method for noninvasive quantification of tissue biomechanical properties in 3D using phase-stabilized swept source optical coherence elastography (PhS-SSOCE). A focused air-pulse delivery system induces an elastic wave, which is then recorded by the PhS-SSOCE system. By calculating the velocity in all radial directions and imaging depths from the origin of the stimulation, a volumetric elasticity map was generated. Utilizing the high spatial sensitivity of PhS-SSOCE, the force applied on the surface of the cornea and subsequent induced deformation amplitude was minimal, thus preserving the structure and function of delicate ocular tissues such as the cornea and sclera. The results show that this noninvasive method for elasticity assessment can provide a volumetric mapping of elasticity and can differentiate untreated and UV-induced collagen cross-linked (CXL) corneas. As expected, the elastic wave velocity and subsequent Young’s modulus was significantly higher in the CXL cornea as compared to the untreated cornea, indicating a substantial increase in corneal stiffness after the CXL treatment.

Original languageEnglish
Title of host publicationOphthalmic Technologies XXV
EditorsArthur Ho, Fabrice Manns, Per G. Soderberg
ISBN (Electronic)9781628413977
DOIs
StatePublished - 2015
Event25th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: 7 Feb 20158 Feb 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9307
ISSN (Print)1605-7422

Conference

Conference25th Conference on Ophthalmic Technologies
Country/TerritoryUnited States
CitySan Francisco
Period7/02/158/02/15

Keywords

  • Optical coherence elastography
  • collagen cross-linking
  • cornea
  • keratoconus

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