TY - JOUR
T1 - Zinc inhibits tumor metastasis by regulating plasminogen activation
AU - Tu, Zhigang
AU - Liang, Jun F.
PY - 2006
Y1 - 2006
N2 - In this study, we found that zinc exerted a dual inhibition effect on plasminogen activator/plasmin system by inhibiting plasminogen activator activation and down-regulating plasmin activity. Zinc demonstrated significant inhibition effects on plasminogen activator and plasmin induced cell morphology change and movement. These results explain the anti-tumor and metastasis blocking effects of zinc observed in clinical studies. In addition, the strong down-regulation effects of zinc on plasminogen activator/plasmin system also suggest the potential role of zinc in other fibrinolysis associated diseases including neurodegenerative diseases.
AB - In this study, we found that zinc exerted a dual inhibition effect on plasminogen activator/plasmin system by inhibiting plasminogen activator activation and down-regulating plasmin activity. Zinc demonstrated significant inhibition effects on plasminogen activator and plasmin induced cell morphology change and movement. These results explain the anti-tumor and metastasis blocking effects of zinc observed in clinical studies. In addition, the strong down-regulation effects of zinc on plasminogen activator/plasmin system also suggest the potential role of zinc in other fibrinolysis associated diseases including neurodegenerative diseases.
KW - Cancer therarpy
KW - Metastasis
KW - Plasminogen activator
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=34248378770&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248378770&partnerID=8YFLogxK
U2 - 10.3923/ijcr.2006.376.382
DO - 10.3923/ijcr.2006.376.382
M3 - Article
AN - SCOPUS:34248378770
SN - 1811-9727
VL - 2
SP - 376
EP - 382
JO - International Journal of Cancer Research
JF - International Journal of Cancer Research
IS - 4
ER -
