Abstract
In this study, we found that zinc exerted a dual inhibition effect on plasminogen activator/plasmin system by inhibiting plasminogen activator activation and down-regulating plasmin activity. Zinc demonstrated significant inhibition effects on plasminogen activator and plasmin induced cell morphology change and movement. These results explain the anti-tumor and metastasis blocking effects of zinc observed in clinical studies. In addition, the strong down-regulation effects of zinc on plasminogen activator/plasmin system also suggest the potential role of zinc in other fibrinolysis associated diseases including neurodegenerative diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 376-382 |
| Number of pages | 7 |
| Journal | International Journal of Cancer Research |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2006 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer therarpy
- Metastasis
- Plasminogen activator
- Zinc
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